NIDDK extramural human-subjects share ~40% sustained FY2014-FY2023

NIDDK's "Funding Trends & Support of Guiding Principles: Human Subjects Research" reports that the percentage of NIDDK funding supporting human-subjects research across all extramural research awards rose from approximately 33% in FY2011 to approximately 40% in FY2014 and has remained at that level through FY2020. The companion "Funding Trends & Support of Core Values" report identifies more than 17,600 awards and over $8.4 billion invested in human-subjects research from FY2014-FY2023, consistent with a sustained ~40% portfolio share through FY2023.

This evidence anchors the Term-B partition used in C-0005: approximately 30-40% of the institution's biomedical output is human-subjects data tied to specific IRB protocols, consent documents, and recruitment windows, for which replacement is not feasible at any price. Original cohorts cannot be reassembled; consent expires; recruitment windows close. The remainder — bench, computational, imaging, and omics work — has a Stern-anchored reconstruction floor (~$250K per paper, E-0036), but the human-subjects fraction is unbounded above, which is why C-0005 reports Term B as a feasible-subset floor with an irreplaceable remainder rather than a single number.