Westbrook & Burley 2019 — PDB contributions to FDA drug approvals 2010-2016

Westbrook, J.D. & Burley, S.K. "How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals." Drug Discovery Today 24(2):412-429, February 2019. doi:10.1016/j.drudis.2018.11.020.

Key facts: 5,914 PDB structures providing structural coverage for 88% of the 210 new molecular entities approved by the U.S. FDA between 2010 and 2016 across all therapeutic areas. More than half of those structures were published and distributed openly more than ten years before drug approval.

Use: Empirical anchor for the open-data multiplier (§7.6) — pre-existing open structural data enables drug development on multi-decade lag.

Original whitepaper reference: [13a]